Synergistic anti-inflammatory and analgesic activity of hydroethanolic extracts of Terminalia macroptera Guill. & Perr. and Ximenia americana L.

Inflammation is the reaction of immune system to an external or internal aggression organism. The symptoms (redness, edema, heat and pain) are secondary increase in vascular permeability. hydroethanolic extract has anti-inflammatory properties vitro. aim was examine analgesic activities extracts alone combination. activity studied using carragenan-induced paw edema type interactions between two determined by combination index on isobologram. Acetic acid-induced torsion Haffner's tail clamp test were performed evaluate activity. At a dose 500 mg/kg, showed percentage inhibition 57.02% 56.53% respectively. Median-Effective Dose 2 (174.02 mg/kg) better than that 1 (186.03 mg/kg). isobologram indicated synergistic interaction constituents combinations. , at mg/kg reduced number twists 46.42; 50.17 65.53% central response maximal (37.36 ± 8.15 seconds) 60 min after administration. combinations synergy effects. peripheral